Home : Unsafe Drugs : Proton Pump Inhibitors

Proton Pump Inhibitors Side Effects

Name: Proton Pump Inhibitors Aciphex Nexium Prevacid Prilosec Protonix
Generic: Raberprazole Esomeprazole Lansoprazole Omeprazole Pantoprazole

Osteoporosis - A condition in which there is a decrease in bone mass and bone density and an increased risk and/or incidence of fracture. Studies show that long term use of PPIs may cause an increased risk of osteoporosis and/or bone fracture.

See our Proton Pump Inhibitors Glossary

Manufacturer: Eisai (Aciphex/Raberprazole) AstraZeneca (Nexium/Esomeprazole and Prilosec/Omeprazole) TAP Pharmaceuticals Inc. (Pevacid/Lansoprazole) Wyeth-Ayerst (Protonix/Pantoprazole)
Date approved: Aciphex was approved in 1999 Nexium was approved in 2001 Prevacid was approved in 2000 Prilosec was approved in 2003 Protonix was approved by the FDA in 2000
Status: On the market
Approved uses: Gastroesophageal Reflux Disease (GERD)
Off-Label uses: Ulcers, Zollinger-Ellison Syndrome, H. Pylori infection of the stomach, Laryngitis
Side effects:
  • Increased risk of hip fracture and other fractures
  • Osteoporosis
  • headaches
  • diarrhea
  • abdominal pain
  • rash
  • dizziness
  • nervousness
  • muscle pain
  • abnormal heartbeat
  • weakness
  • leg cramps
Related topics: Acid Reflux Disease, Osteoporosis, Prevacid, Prilosec
Common Misspellings: PPIs, proton pump, proton pump inhibitors, proton pump inhibitor, proton pumps, PPI, PPI's
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Proton Pump Inhibitors

Proton Pump Inhibitors (PPIs) are a group of drugs that work to reduce gastric acid production. The stomach contains a pump that produces gastric acid; PPIs bind this pump and prevent acid from being pumped into the stomach. Medications such as Prilosec, Prevacid, Nexium and Aciphex are prescribed to patients with gastroesophageal reflux disease (GERD), dyspepsia, ulcers, Zollinger-Ellison Syndrome and sometimes stomach infections.

Although most side effects of Proton Pump inhibitors are minor, PPIs have recently been linked to an increased risk of bone fractures. In particular, those who have been on a PPI for 5 or more consecutive years are at a greater risk of hip fracture. Those who have been on a PPI for 7 plus years are at greater risk of fractures in general and osteoporosis.

Details of Proton Pump Inhibitor Drugs' Use and Side Effects

A group of drugs known as Proton Pump Inhibitors (PPIs) were recently discovered to be linked with severe bone fractures and bone density loss among patients. In August 2008, the Canadian Medical Association Journal found that PPIs may reduce calcium absorption, thus causing early onset osteoporosis and bone fracture among patients, especially those taking PPIs for five to seven years or longer. According to an American Medical News article from September 2008, the National Osteoporosis Foundation reports that approximately 44 million Americans, which accounts for 55 percent of the 50-years-of-age or older population suffer from osteoporosis and bone fractures. read more

Proton Pump Inhibitors May Lead to Osteoporosis

Heartburn and acid reflux disease are among some of the most common ailments of US citizens and patients across the world. Gastroesophageal reflux disease is treated in patients by the millions every year in in the U.S. Therefore, it is not surprising that Proton Pump Inhibitors (PPIs) - a class of stomach acid reduction drugs - represent a $14 billion dollar industry. read more

View the Proton Pump Inhibitors Law Articles page here

Proton Pump Inhibitors Jury Verdicts

______ $1,509,638 - Medical Malpractice Medical Malpractice - Gastric Cancer - Diagnosis - Wrongful Death - Settlement

______ $500,000. See Editor's Note. - Medical Malpractice Medical Malpractice - Myocardial Infarction - Diagnosis - Wrongful Death - Settlement

View the Proton Pump Inhibitors Jury Verdicts page here

Proton Pump Inhibitors Glossary

Abdominal

Absorption

View the Proton Pump Inhibitors Glossary page here

Proton Pump Inhibitors Government Articles

Powerful Antacid Drugs Raise Fracture Risk

Relief of symptoms from proton-pump inhibitor treatment does not necessarily confirm diagnosis of GERD

View the Proton Pump Inhibitors Government Articles page here

Proton Pump Inhibitors News Articles

Cure for persistent hiccups still elusive - San Antonio Express-News

Hiatal Hernia Basics

View the Proton Pump Inhibitors News Articles page here

Proton Pump Inhibitors Newsfeeds

Airport noise complaints get a boost

PRC, City Hall looking to streamline pier management

View the Proton Pump Inhibitors Newsfeeds page here

Proton Pump Inhibitors Useful Web Sites

Medicine.net Information on Proton Pump Inhibitors

Science Daily Article on PPIs and Bone Fracture

View the Proton Pump Inhibitors Useful Web Sites page here

Proton Pump Inhibitors Wikipedia

Proton-pump inhibitor

Gastroesophageal reflux disease

View the Proton Pump Inhibitors Wikipedia page here

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