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Home : Unsafe Drugs : Proton Pump Inhibitors : Law Articles : Proton Pump Inhibitors May Lead to Osteoporosis Proton Pump Inhibitors May Lead to OsteoporosisHeartburn and acid reflux disease are among some of the most common ailments of US citizens and patients across the world. Gastroesophageal reflux disease is treated in patients by the millions every year in in the U.S. Therefore, it is not surprising that Proton Pump Inhibitors (PPIs) - a class of stomach acid reduction drugs - represent a $14 billion dollar industry. Since their FDA approval in 2006, PPIs have been prescribed to millions of patients who suffer from heartburn, acid reflux, ulcers and other stomach conditions dealing with the production of hydrochloric acid. PPIs encompass a number of different brands of prescription and over-the-counter medication. Some of the most popular are Prilosec, Nexium, Aciphex, and Prevacid. As the most powerful stomach acid blocker available, proton pump inhibitors are very popular and patients often wish to stay on them permanently. PPIs are a prevention/relief medication and do not provide any healing or permanent remedy to gastric acid problems. Once a patient goes off of a PPI, the acid reflux will return. As medications go, PPIs have been regarded by the medical community as relatively safe until recently, when new studies showed increased risk of bone fracture and osteoporosis with long-term use of a PPI. Those patients who have been taking a proton pump inhibitor continuously for 5-7 years are at an increased risk for hip fracture after 5 years of exposure and increased risk for any fracture after 7 years of exposure. Proton pump inhibitors work by binding to a pump in the stomach and preventing the production and secretion of hydrochloric acid. Hydrochloric acid is the cause of many acid-related health problems such as GERD (gastroesophageal reflux disease). However, hydrochloric acid also helps the body to break down and absorb nutrients such as calcium. When hydrochloric acid secretion is prevented by a PPI, it affects the body's ability to absorb calcium effeciently, and thereby causes lower bone density and increased risk of fracture over a long period of time. Given this information, patients who are already at risk for osteoporosis should weigh the benefits and risks of taking a proton pump inhibitor medication. If you have taken a PPI for many years and feel that it has affected your bone health, you should speak to your physician about whether you should continue or discontinue your use of the PPI. You may also want to contact a qualified personal injury attorney. See below for information on how to contact a qualified PPI lawyer. |




